What Causes Liver Enlargement In Dogs. Primary or secondary cancer in dogs is another possible cause of elevated liver enzymes in dogs. There are a number of diseases that can affect the functioning of a dog’s liver and lead to enlargement.
The body naturally increases the release of cortisol from the adrenal glands during times of stress as part of the “fight or flight” response. What causes enlarged liver in dogs? Liver disease is more common in older adult dogs than it is in younger dogs.